Paola Pizzo Selected Research

Presenilin-2

6/2021	Familial Alzheimer's disease presenilin-2 mutants affect Ca2+ homeostasis and brain network excitability.
1/2021	Calcium Signaling and Mitochondrial Function in Presenilin 2 Knock-Out Mice: Looking for Any Loss-of-Function Phenotype Related to Alzheimer's Disease.
1/2021	Loosening ER-Mitochondria Coupling by the Expression of the Presenilin 2 Loop Domain.
1/2020	Intracellular Calcium Dysregulation by the Alzheimer's Disease-Linked Protein Presenilin 2.
1/2020	Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks.
12/2019	PSEN2 (presenilin 2) mutants linked to familial Alzheimer disease impair autophagy by altering Ca2+ homeostasis.
9/2016	Characterization of the ER-Targeted Low Affinity Ca(2+) Probe D4ER.
1/2016	Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2.
5/2013	Modulation of the endoplasmic reticulum-mitochondria interface in Alzheimer's disease and related models.
10/2012	Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2.

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Paola Pizzo Research Topics

Disease

22	Alzheimer Disease (Alzheimer's Disease) 06/2021 - 03/2004
3	Neoplasms (Cancer) 03/2022 - 01/2017
3	Neuroblastoma 01/2021 - 05/2013
2	Mitochondrial Diseases (Mitochondrial Disease) 01/2021 - 01/2018
2	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020 - 07/2004
1	Breast Neoplasms (Breast Cancer) 03/2022
1	Amyloid Plaque 01/2021
1	Nervous System Diseases (Neurological Disorders) 01/2021
1	Colonic Neoplasms (Colon Cancer) 01/2020
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Inflammation (Inflammations) 01/2018
1	Pain (Aches) 08/2010
1	Snake Bites (Snake Bite) 08/2010
1	Necrosis 02/2010
1	Dementia (Dementias) 04/2005
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 07/2004
1	Hairy Cell Leukemia 07/2004
1	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 07/2004
1	Lymphoma (Lymphomas) 07/2004

Drug/Important Bio-Agent (IBA)

13	Presenilin-2IBA 06/2021 - 03/2004
11	Flavin-Adenine Dinucleotide (FAD)IBA 01/2021 - 03/2004
9	Proteins (Proteins, Gene)FDA Link 03/2022 - 08/2008
7	PresenilinsIBA 01/2019 - 03/2004
5	Presenilin-1IBA 01/2021 - 06/2006
5	Amyloid (Amyloid Fibrils)IBA 01/2021 - 08/2008
5	Peptides (Polypeptides)IBA 01/2021 - 02/2010
4	CalciumIBA 01/2020 - 06/2006
3	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021 - 08/2008
2	Adenosine Triphosphate (ATP)IBA 01/2021 - 08/2010
2	Phospholipases (Phospholipase)IBA 08/2010 - 02/2010
2	NeurotoxinsIBA 08/2010 - 02/2010
1	glucose-regulated proteinsIBA 03/2022
1	Oxidants (Oxidizing Agents)IBA 03/2022
1	AntioxidantsIBA 03/2022
1	Amyloid beta-PeptidesIBA 01/2021
1	Glutamic Acid (Glutamate)FDA Link 01/2021
1	HexokinaseIBA 01/2020
1	Pyruvic Acid (Pyruvate)IBA 01/2020
1	Proton-Translocating ATPases (ATPase, H+)IBA 12/2019
1	Inositol (Myoinositol)IBA 12/2019
1	Bovine Serum AlbuminIBA 12/2019
1	Red Fluorescent ProteinIBA 12/2019
1	Mechanistic Target of Rapamycin Complex 1IBA 12/2019
1	AMP-Activated Protein KinasesIBA 12/2019
1	Amyloid beta-Protein Precursor (Amyloid Protein Precursor)IBA 12/2019
1	Cyan Fluorescent ProteinIBA 12/2019
1	1,2- bis(2- aminophenoxy)ethane- N,N,N',N'- tetraacetic acid (BAPTA)IBA 12/2019
1	Ethylene Glycol (Monoethylene Glycol)IBA 12/2019
1	Sirolimus (Rapamycin)FDA Link 12/2019
1	Vacuolar Proton-Translocating ATPases (V-Type ATPase)IBA 12/2019
1	polyglutamineIBA 12/2019
1	Small Interfering RNA (siRNA)IBA 12/2019
1	Green Fluorescent ProteinsIBA 12/2019
1	Lysosomal-Associated Membrane Protein 1IBA 12/2019
1	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl esterIBA 12/2019
1	EGTA acetoxymethyl esterIBA 12/2019
1	bafilomycin A1IBA 12/2019
1	Ether (Diethyl Ether)IBA 12/2019
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 12/2019
1	EstersIBA 12/2019
1	mitochondrial calcium uniporterIBA 12/2019
1	Adenosine Triphosphatases (ATPase)IBA 12/2019
1	Phosphotransferases (Kinase)IBA 12/2019
1	AcidsIBA 12/2019
1	Glucose (Dextrose)FDA LinkGeneric 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018
1	Mitochondrial DNA (mtDNA)IBA 01/2018
1	Free RadicalsIBA 01/2018
1	LipidsIBA 01/2018
1	NAD (NADH)IBA 01/2018
1	PotassiumIBA 08/2010
1	ChemokinesIBA 07/2004

Therapy/Procedure

2	Therapeutics 01/2017 - 08/2008